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The discovery of adult hippocampal neurogenesis has added a whole new dimension to research on structural plasticity in the adult and aging hippocampus. Plasticity is the basis for how the brain adapts to changes over time. The hippocampus is one of the brain regions that is prominently affected by neurodegeneration and functional decline even in what is still considered “normal aging”. Advancing age constitutes a primary risk factor for disease of the central nervous system most notably neurodegenerative disorders. The demographic changes in the foreseeable future stress the need for research on successful cognitive aging.
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